Robert Jacks, co-founder and former chief financial officer of Symbiomix Therapeutics, has taken over the reins of Cambridge, Mass.-based Indalo Therapeutics and will help guide the company in the development of therapies for patients suffering from serious fibrotic diseases such as NASH and idiopathic pulmonary fibrosis (IPF).
Jacks assumes the helm of the company as it aims to take its lead fibrotic drug candidate, IDL-2965, into the clinic this year. IDL-2965 is an oral, selective, RGD-binding integrin antagonist that inhibits the activation of TGF-β as well as the ability of the stiff extracellular matrix to promote fibroblast migration and survival. IDL-2965 displays potent antifibrotic efficacy at low once-daily doses across multiple models of disease in vital organ systems, including the liver, lung and kidney. Indalo has completed a rigorous set of GLP toxicology and safety-pharmacology studies with IDL-2965 in preparation for human studies and has designed an efficient and adaptive Phase I program that enables assessment of safety, PK and biomarker-based proof of mechanism in NASH and IPF patients, the company said.
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